One of the main uses of Nipruss is to control severe high blood pressure. When patients suffer from a hypertensive crisis that does not respond to other treatments, Nipruss may be used as an enhancer to reach safer and faster blood pressure levels. This drug has a rapid effect, as it starts working within minutes, making it an ideal choice in emergency situations. Nipruss is also used to treat some cases of heart failure. In these cases, its vasodilatory properties help reduce the load on the heart and increase blood flow, which contributes to relieving the annoying symptoms for patients.